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Assays, reagents, kits, and other assorted products used to detect cellular apoptosis, determine the activity levels of caspase or cathepsin, or identify similar cellular activity.
A potent, reversible, and highly selective isatin sulfonamide-based inhibitor of caspase-3 (Ki(app) = 60 nM; IC50 = 120 nM) and caspase-7 (Ki(app) = 170 nM); inhibits apoptosis in camptothecin treated Jurkat cells (IC50 = ~50 µM) and in chondrocytes (44% inhibition at 10 µM and 98% inhibition at 50 µM)
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Irreversible, cell permeable inhibitor of caspase-1. Inhibits also caspase-4. Alternative name: Caspase 1 inhibitor (fluoromethylketone)or. MW: 630.7. Purity: ≥99% (HPLC). Formulation: Liquid. In DMSO. Long Term Storage: -20°C.
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An Asc-1 inhibitor selectively inhibits Asc-1 in HEK293 cells expressing Asc-1 (IC50 36.8 nM) over 40 other transporters (IC50s >10 UM) inhibits serine cysteine glycine and alanine import and cAMP-induced increases in the OCR and decreases UCP1 levels in primary human white and brown adipose cells at 100 nM decreases the number of malformed neurons and reduces contextual fear memory deficits in a mouse model of surgery-induced brain damage when intracerebroventricularly infused
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